Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development

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Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development.

LIM-homeodomain transcription factors (LIM-HDs) are essential in tissue patterning and differentiation. But their expression patterns in the inner ear are largely unknown. Here we report on a study of twelve LIM-HDs, by their tempo-spatial patterns that imply distinct yet overlapping roles, in the developing mouse inner ear. Expression of Lmx1a and Isl1 begins in the otocyst stage, with Lmx1a e...

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Specific expression of the LIM/homeodomain protein Lim-1 in horizontal cells during retinogenesis.

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The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes.

LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies, but their identity as direct LMX1B targets remains hypothetical. We describe here the first molecular characterization of LMX1B target gene regulation. Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa ...

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Reelin-expressing Cajal-Retzius (CR) cells are among the earliest generated cells in the mammalian cerebral cortex and are believed to be crucial for both the development and the evolution of a laminated pattern in the pallial wall of the telencephalon. LIM-homeodomain (LIM-hd) transcription factors are expressed during brain development in a highly restricted and combinatorial manner, and they...

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ژورنال

عنوان ژورنال: Developmental Dynamics

سال: 2008

ISSN: 1058-8388,1097-0177

DOI: 10.1002/dvdy.21735